What to know
Absorbed only in the terminal ileum, so ileal Crohn's and resection make deficiency likely. A Dutch RCT found extra B12 does not relieve fatigue in people who aren't deficient, so test first. Liquid methylcobalamin bypasses the digestive problem.
Reference 138
Evidence & Andrew’s score
Evidence
3Andrew
—Product selection
Pure Encapsulations B12 Liquid (methylcobalamin)
go.supplementsforibd.com/b12
go.supplementsforibd.com/b12
References
- Scholten AM, et al. Surplus vitamin B12 use does not reduce fatigue in patients with irritable bowel syndrome or inflammatory bowel disease: a randomized double-blind placebo-controlled trial. Clin Nutr ESPEN 2018 (listed in a 2025 integrative review of pharmacological treatments for IBD fatigue).
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Options to explore with your care team. These are not a recommendation to take them together. Andrew earns a commission on Fullscript purchases. US shipping only.