What to know
Erinacines and hericenones; improvement in a mouse UC model. A 2024 Italian retrospective study found a lion's-mane-based multi-compound add-on (with berberine, quercetin, niacin and biotin) improved response to mesalazine in mild-to-moderate UC. Mycelium-on-rice product.
Reference 68
Evidence & Andrew’s score
Evidence
3Andrew
—Product selection
Host Defense Lion's Mane
go.supplementsforibd.com/lions-mane
go.supplementsforibd.com/lions-mane
References
- Tursi A, D'Avino A, Brandimarte G, et al. Enhancing oral 5-ASA effectiveness in mild-to-moderate ulcerative colitis through an H. erinaceus-based nutraceutical add-on multi-compound: the HERICIUM-UC two-arm multicentre retrospective study. Pharmaceutics 2024;16(9):1133.
READ & SHOP
Explore related supplements
Microbiome Modulating
Berberine
The one antimicrobial botanical with real IBD evidence, and more of it than I expected: a 2024 meta-analysis pooled ten randomized trials (952 patients, mostly from…
Evidence 5/5Andrew 2/5
The Five
Quercetin
Quercetin is the workhorse flavonoid of the plant kingdom and one of the most-studied antioxidants in existence, in cells and in animals. In people with IBD, it has…
Evidence 2/5Andrew 5/5
Vitamins & Minerals
Niacin (B3)
Signals through GPR109A, the same receptor as butyrate, in colonic epithelium. In the multivitamin.Reference 149
Evidence 1/5Andrew —/5
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