What to know
Andrew wants this one emphasized: a zinc-carnosine chelate that stays in contact with the gut lining, developed in Japan as an ulcer drug (polaprezinc). In a London crossover trial, 37.5 mg twice daily completely prevented the threefold rise in gut permeability that five days of indomethacin caused in volunteers, and it stimulated gut-cell repair in the lab; a later trial paired it with colostrum against exercise-induced leak. One of the few entries with human data on the tight junctions themselves; no IBD trial yet. Contains magnesium stearate.
References 103–104
Evidence & Andrew’s score
Evidence
3Andrew
—Product selection
Integrative Therapeutics Zinc-Carnosine (PepZinGI)
go.supplementsforibd.com/zinc-carnosine
go.supplementsforibd.com/zinc-carnosine
References
- Mahmood A, FitzGerald AJ, Marchbank T, et al. Zinc carnosine, a health food supplement that stabilises small bowel integrity and stimulates gut repair processes. Gut 2007;56(2):168–175. (Crossover trial, 10 volunteers: 37.5 mg twice daily prevented the threefold rise in gut permeability caused by indomethacin.)
- Davison G, Marchbank T, March DS, Thatcher R, Playford RJ. Zinc carnosine works with bovine colostrum in truncating heavy exercise-induced increase in gut permeability in healthy volunteers. Am J Clin Nutr 2016;104(2):526–536.
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